整合素α2β1与药物性牙龈增生相关性的研究进展
Research progression of the relationship between integrin α2β1 and drug-induced gingival overgrowth
作者：康颖竹, 郭淑娟, 刘程程, 丁一
Author：Yingzhu Kang, Shujuan Guo, Chengcheng Liu, Yi. Ding
收稿日期：2016-03-15 年卷（期）页码：2017,35(1):99-99-103
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：药物性牙龈增生,整合素α2β1,胶原代谢,胶原吞噬,
Key words：drug-induced gingival overgrowth,integrin α2β1,collagens metabolism,collagen phagocytosis,
基金项目：卫生部牙周科国家临床重点专科建设项目（2010）
中文摘要
药物性牙龈增生（DIGO）是指长期服用某些药物而引起的牙龈组织的纤维性增生和体积增大。牙龈细胞增多与胞外基质尤其是胶原蛋白的大量沉积是其主要病理表现。近年来研究表明,整合素α2β1与胶原吞噬作用密切相关,在DIGO的发生发展中发挥了重要作用。本文就整合素α2β1与DIGO相关性的研究进展进行综述。
英文摘要
Drug-induced gingival overgrowth (DIGO) is characterized by fibrous gingival hyperplasia and increased gin-gival volume. DIGO is histologically associated with proliferation of cells and deposition of extracellular matrices, particularly collagen. Integrin α2β1 is related to collagen phagocytosis and involved in the occurrence and progression of DIGO. This paper reviews the progress of research on the relationship between integrin α2β1 and DIGO.
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