Objective This study aims to investigate the prevalence and distribution of teeth number and morphology abnormalities in Chinese pediatric patients’ permanent teeth at the mixed dentition stage by performing panoramic radiographs analysis. Methods A total of 4 347 panoramic radiographs of pediatric patients aged 5 years to 15 years who were admitted to the hospitals from September 2011 to September 2013 were reviewed. The presence of teeth number and morphology abnormalities were recorded as follows: congenitally absent teeth, supernumerary teeth, odontoma, microdontia, fused teeth, dilaceations, and cusp deformity. SPSS 16.0 software was used for statistical analysis. Results The prevalence of teeth number and morphology abnormalities in pediatric patients’ permanent teeth was 31.79% (1 382/4 347). The prevalence was higher in males. Significant difference between the genders was observed (PP