双膦酸盐相关性颌骨坏死并发腕部舟状骨骨髓炎1例
Bisphosphonate-related osteonecrosis of the jaw complicated with wrist scaphoid osteomyelitis: a case report
作者：孙照薇,李志勇,余丹,朱洁颖,张伊殿,朱鑫美
Author：Zhaowei Sun,Zhiyong Li,Dan Yu,Jieying Zhu,Yidian Zhang,Xinmei Zhu
收稿日期：2018-06-10 年卷（期）页码：2019,37(2):224-224-228
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：双膦酸盐,颌骨坏死,舟状骨骨髓炎,唑来膦酸,
Key words：bisphosphonate,osteonecrosis of the jaw,scaphoid osteomyelitis,zoledronic acid,
基金项目：
中文摘要
双膦酸盐类药物可以抑制破骨细胞功能,使颌骨骨密度升高,血流减少,发生骨坏死。双膦酸盐类药物相关性骨坏死多发于颌骨。本文报道1例双膦酸盐相关性颌骨坏死并发腕部舟状骨骨髓炎,并结合文献讨论双膦酸盐药物性颌骨坏死的发病机制、治疗与预防等。
英文摘要
Bisphosphonates can directly inhibit osteoclasts, which may lead to increased bone density, reduced blood flow, and osteonecrosis of the jaw. Bisphosphonate-related osteonecrosis is usually observed in the jaw bone. In this article, we report a patient with bisphosphonate-related osteonecrosis of the jaw (BRONJ) complicated with wrist scaphoid osteo-myelitis. Furthermore, we introduce the pathogenesis, treatment, and prevention of BRONJ.
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