牙龈卟啉单胞菌双组分信号转导系统的研究进展
Research progress on two-component signal transduction systems in Porphyromonas gingivalis
作者：尧可, 蔡靖仪, 赵蕾, 吴亚菲, 赵志河, 申道南
Author：Yao Ke, Cai Jingyi, Zhao Lei, Wu Yafei, Zhao Zhihe, Shen Daonan
收稿日期：2019-05-31 年卷（期）页码：2021,39(1):88-88-93
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：牙龈卟啉单胞菌,双组分信号转导系统,基因调控,
Key words：Porphyromonas gingivalis,two-component signal transduction systems,gene regulation,
基金项目：国家自然科学基金面上项目(81771077);四川省科技计划重点研发项目(2018SZ0161)
中文摘要
牙龈卟啉单胞菌被认为是主要的牙周致病菌之一，与慢性牙周炎发生发展密切相关。面对复杂的口腔环境，牙龈卟啉单胞菌必须及时感知环境变化并作出反应，双组分信号转导系统在其中具有重要作用。双组分信号转导系统通常由组氨酸激酶和反应调节蛋白组成，通过控制蛋白的磷酸化状态调节信号传导。近年来，有关牙龈卟啉单胞菌的双组分信号转导系统陆续被报道。本文就牙龈卟啉单胞菌的双组分系统的组成和功能进行综述。
英文摘要
Porphyromonas gingivalis(P. gingivalis), a Gram-negative oral anaerobe, is considered to be a major pathogenic agent involved in the onset and progression of chronic periodontitis.P. gingivalismust be able to perceive and respond to the complicated changes in host to survive the environmental challenges, in which the two-component signal transduction systems (TCSs) play critical roles by connecting input signals to cellular physiological output. Canonical TCS consists of a sensor histidine kinase and a cognate response regulator that functions via a phosphorylation cascade. In this review, the roles of TCSs inP. gingivaliswere demonstrated by illustrating the target genes and modulation modes, which may help elucidate the underlying mechanisms in future studies.
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