屏障材料自体浓缩生长因子膜和骨胶原在后牙区牙槽嵴保存术中的应用：一项1年随访的前瞻性队列研究
Concentrated growth factor and collagen as barrier materials in alveolar ridge preservation for posterior teeth: a prospective cohort study with one-year follow-up
作者：朱湛枫, 杨婷婷, 陈沁怡, 邱伟恩, 黎詠珊, 林意蓝, 班宇
Author：Zhu Zhanfeng, Yang Tingting, Chen Qinyi, Qiu Weien, Li Yongshan, Lin Yilan, Ban Yu
收稿日期：2023-12-27 年卷（期）页码：2024,42(3):346-346-352
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：牙槽嵴保存术,自体浓缩生长因子,骨胶原,
Key words：alveolar ridge preservation,concentrated growth factor,collagen,
基金项目：四川省医学科研课题计划(S23029);四川大学华西口腔医院探索与研发项目(LCYJ2022-YY-4)
中文摘要
目的 评价自体浓缩生长因子（CGF）膜和骨胶原作为屏障材料在后牙区牙槽嵴保存术（ARP）术后1年的骨组织保存效果。 方法 选取三壁及以上骨缺损需接受后牙区牙槽嵴保存术治疗的24例患者为研究对象，随机分配至CGF组（12例）和骨胶原组（Collagen组）（12例）。2组患者均拔除无法保留后牙，拔牙窝内填充异种移植物骨替代物Bio‐Oss®至拔牙前牙槽嵴顶处，CGF组将制取的CGF膜覆盖于骨替代材料上缘并封闭创口，Collagen组采用Bio-Oss® Collagen覆盖并封闭创口。牙槽峭保存术后6个月植入种植体。采用锥形束CT测量分析术后即刻、6个月和1年的垂直牙槽嵴骨高度和水平牙槽嵴骨宽度变化，评估种植术中再植骨率和植体存留率。采用SPSS 28.0软件对数据进行统计学分析。 结果 24例患者均完成术后1年随访，无1例退出试验或失访，无1例出现术后感染、出血和种植体周病等。术后6个月CGF组的垂直牙槽嵴骨高度减少量低于Collagen组，差异有统计学意义（P<0.05）；术后1年CGF组和Collagen组垂直牙槽嵴骨高度的减少量差异无统计学意义（P>0.05）。术后6个月、术后1年CGF组和Collagen组水平牙槽嵴骨宽度的减少量差异均无统计学意义（P>0.05）。2组种植术中再植骨率均为16.7%，植体存留率为100%。 结论 CGF膜和Bio-Oss® Collagen作为后牙区牙槽嵴保存术的屏障材料，均能有效减少拔牙后牙槽骨吸收，保存牙槽骨。
英文摘要
ObjectiveThis study aims to evaluate the efficacy of concentrated growth factor (CGF) membrane and collagen as barrier materials in sealing the alveolar socket in alveolar ridge preservation (ARP) in the posterior region during a one-year follow-up.MethodsA total of 24 patients who underwent ARP in the posterior region were selected for inclusion and randomly assigned to the CGF group (12 cases) and Collagen group (12 cases). The patients in both groups underwent extraction of posterior teeth. The extraction sockets were filled with a bone substitute to the level of the pre-extraction buccal and lingual or palatal alveolar bone plates. The wounds in the CGF group were closed with a fabricated CGF overlaying the upper edge of the bone substitute material, whereas those in the Collagen group were closed with Bio-Oss Collagen. The implants were placed after 6 months. The evaluation was based on implant retention, re-grafting rate, and vertical and horizontal alveolar ridge bone volume changes measured by cone beam computed tomography (CBCT). Data were statistically analyzed using SPSS 28.0 software.ResultsNo patient withdrew throughout the follow-up period. No implant failure and no severe peri-implant or mucosal soft tissue complications were observed. Six months after the operation, the degree of vertical alveolar ridge height resorption in the CGF group was lower than that in the Collagen group (P<0 .05). there were no statistically difference between the groups at 1 year after the operation (P>0.05). The amount of bone reduction in horizontal alveolar ridge width showed no difference between the groups at 6 months and 1 year after surgery (P>0.05).ConclusionCGF membrane and Bio-Oss Collagen as barrier materials for posterior ARP inhibited reduction in alveolar ridge bone mass.
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