The primary objectives of orthodontic treatment in adult patients with periodontal disease are to improve dental alignment and occlusal relationships, optimize oral hygiene conditions, restore masticatory function, and enhance aesthetic outcomes. During treatment, orthodontists should comprehensively and continuously evaluate the patient’s periodontal health status, adopt personalized biomechanical control strategies, enhance multidisciplinary collaboration, and implement targeted prevention and management measures for potential orthodontic risks. This article provides an overview of common clinical issues encountered in the orthodontic treatment of adult periodontal patients. Key areas addressed include the relationship between periodontal disease and the development of malocclusion, the formulation of treatment objectives, indications and contraindications, key aspects of treatment process control, the role of radiographic examination in treatment planning and monitoring, and post-orthodontic retention protocols.