ObjectiveTo investigate the clinical application safety of dental adhesives and composite resin-based dental materials.MethodsA non-targeted screening of migrants from clinically used dentin adhesives and composite resin materials was conducted using gas chromatography-mass spectrometry (GC-MS). Migration media included saliva simulants with pH of 5.5, 6.2, 7.4, and 8.0, 50% ethanol solution, and ultrapure water. By simulating migration under va-rious oral environments, six migrants were detected in the migration media. GC-MS/flame ionization detector was used for quantitative analysis of these migrants, and risk assessment was performed by combining their toxicity data.ResultsIn all six migration media, the exposure levels of monomers and photoinitiators released from four commercially avai-lable resin-based dental materials were all within established safety thresholds.ConclusionThis study conducted nontargeted detection and safety assessment of migrants from dental restorative materials. The exposure levels of all detected compounds were below safety limits, providing scientific evidence supporting the clinical safety of composite resin-based dental materials.
