新型血液净化材料及佩戴式人工肾的研究构想和预期成果展望
Research Framework and Anticipated Results of Novel Blood Purification Materials and Wearable Artificial Kidney
作者：赵长生(四川大学 高分子科学与工程学院, 四川 成都 610065)；赵伟锋(四川大学 高分子科学与工程学院, 四川 成都 610065)；张翔(四川大学 高分子科学与工程学院, 四川 成都 610065)；贾凌云(大连理工大学 生命科学与技术学院, 辽宁 大连 116024)；苏白海(四川大学 华西医院肾内科, 四川 成都 610041)；周建辉(中国人民解放军总医院 肾脏病科, 北京 100853)
Author：ZHAO Changsheng(College of Polymer Sci. and Eng., Sichuan Univ., Chengdu 610065, China)；ZHAO Weifeng(College of Polymer Sci. and Eng., Sichuan Univ., Chengdu 610065, China)；ZHANG Xiang(College of Polymer Sci. and Eng., Sichuan Univ., Chengdu 610065, China)；JIA Lingyun(College of Life Sci. and Technol., Dalian Univ. of Technol., Dalian 116024, China)；SU Baihai(Nephrology Dept. of West China Hospital, Sichuan Univ., Chengdu 610041, China)；ZHOU Jianhui(Nephrology Dept., Chinese PLA General Hospital, Beijing, 100853, China)
收稿日期：2018-01-06 年卷（期）页码：2018,50(1):1-8
期刊名称：工程科学与技术
Journal Name：Advanced Engineering Sciences
关键字：血液净化治疗;高通抗凝血液透析器;高效特异性血液灌流器;佩戴式人工肾
Key words：Blood purification;anticoagulant high flux hemodialyzer;efficient and specific hemoditoxifier;wearable artificial kidney
基金项目：国家重点研发计划资助项目（2016YFC1103000）
中文摘要
目前，安全有效、特异高效、集成便携成为血液净化耗材及体外循环设备的发展方向。为解决临床和产业重大需求，满足先进血液净化材料及设备的迫切需求，凝练了4个关键研究目标：1）聚醚砜原材料、纺丝生产线、血液透析膜和滤器实现国产化，研发小型血液透析器和血滤器。2）研发与个体化治疗配套的高效特异抗体、β2-微球蛋白和内毒素吸附剂。3）研发佩戴式人工肾装置。4）建立产学研医实时联动机制和评价规范。相应地，研究内容包含：1）解决聚醚砜生产的稳定性和纯化技术、中空纤维膜血液相容性，研发聚醚砜原材料、纺丝生产线、抗凝高通血液透析膜和滤器。2）解决高效特异吸附材料的可控合成、仿生分子刷的有效控制和特异抗体的批量生产，研发高效特异β2-微球蛋白、内毒素吸附剂，建立抗体吸附剂生产线。3）解决微型泵和微型监测装置的制备技术和透析液的再生，研发佩戴式人工肾装置。4）解决生物材料和医疗器械的研发与临床脱节问题，建立产学研医全程实时联动体系和临床评价平台。基于以上内容，以期为国内乃至世界尿毒症患者带来福音，基本解决此类病症对人类和社会所造成的危害。
英文摘要
Nowadays,blood purification technology is required to improve the life qualities and work abilities of the patients.Herein,To meet the demands of clinic and industry,and the desires of the advanced blood purification materials and equipments,the close cooperations among industry,study,research and medicine,and the systematical connections among innovation,industry and clinical practise,four objectives will be achieved:1)localization of polyethersulfone raw material,spinning production line,dialysis membrane and blood dialyzer:research and development of miniature blood dialyzer and filter;2)research and development of efficient specific antibody,β2-microglobulin and endotoxin adsorbents,which can match with the individual treatment of the patients;3)research and development of wearable artificial kidney;4)establishment of evaluation standards and real-time communication system among industry,study,research and medicine.Correspondingly,the research contents of the project are as following:1)improve the property stability of polyethersulfone product via new purification technology;improve the biocompatibility of hollow fiber membrane;research and establish spinning production line;research and produce polyethersulfone raw material,anticoagulant high flux dialysis membrane and dialyzer;2)accurately compound efficient specific adsorbents and biomimetic molecular brush;produce specific antibody in quantity;research and develop efficient specific β2-microglobulin and endotoxin adsorbents;establish the adsorbent production line;3)overcome the technical difficulty of miniature pump and monitoring device fabrication and dialysate regeneration;research and develop wearable artificial kidney;4)build a bridge between clinical applications and scientific research of biomaterials and medical instruments;establish real-time communication system among industry,study,research and medicine;establish platform of clinical evaluation.We believe that by this project research,the domestic blood purification technology,including the material production and method improvement,will make significant advance and breakthrough;the suffering will be reduced and the harms of uremia to humanity and society will be prevented basically.
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