Based on the Shiono and Knight method(SKM) and the secondary flow motion characteristics,the determination of the lateral distribution of depth-averaged velocity in compound channels with one-line vegetation along the edge of the floodplain was proposed.The results showed that there is large disagreement between the computed results and the experiment data,especially in the main channel,when the secondary flow is ignored.When using the traditional divisions of sub-region, the prediction doesn’t largely agree with the experiment data. However,the results showed that by considering the effect of secondary flow,increasing the division of sub-regions and adjusting the available parameters for each region,the proposed method can be capable of predicting the lateral distributions of depth-averaged velocity in this type of channel.