The conceptual design of complex product can be considered as a process which involves intensive iteration,complex reasoning and mutual cooperation among the design groups of various disciplinary areas. In order to provide support for computer-aided design,the conceptual design model of product design with multidisciplinary collaboration was first established,the collaborative mechanism of function,behavior and structure was studied, and the reciprocating mapping of vertical collaborative was analyzed.Then,based on the Muti-Agent,the implementation framwork with multidisciplinary collaboration in conceptual design was built and the solving and reasoning mechanism between Agents with multidisciplinary collaboration were also established.Finally, the conceptual design process of a certain type of wire printer was used to illustrate the application of the proposed method and demonstrate its innovation.