For the development and utilization of collagen,the influences of N-hydroxysuccinimide activated adipic acid derivative (NHS-AA) on the steady flow,dynamic viscoelasticity,thixotropy and creep of collagen solution were studied by the rheometer.The results showed that the solutions cross-linked by different doses of NHS-AA were all pseudoplastic.The viscosity of collagen solutions increased with the increase of the dose of NHS-AA. The elastic modulus of collagen solutions increased dramatically due to the addition of NHS-AA and that indicated that NHS-AA reinforced the elasticity of collagen solution.The thixotropy of collagen solution became strong after adding NHS-AA,suggesting that the recovery of network structure broken by shear stress became slow.Adding NHS-AA resulted in the decrease of the compliance of collagen solution，reflecting that the cross-linked collagen solution was more difficult to transform with shear stress.All the experiments results indicated that the rheological properties of collagen solution could be adjusted by NHS-AA.
