Base on several large-scale triaxial test results of the red layer non-cohesive soil rock mixture in Sichuan Basin, variation rules of strength parameters with the dry density, gravel content and the maximum particle size were studied. The relational expression between the strength parameters and the control factors was obtained by the least square method. The multi-factors predictive mathematical model of the earth-rock mixture strength parameters was established and confirmed. This prediction model is useful for the strength parameters prediction of the similar earth-rock mixture.