To study the preparation of nanospheres (NPs) surface-modified with glycyrrhetinic acid(GA) targeting to hepatocytes.The two GA-NH-PBLG material with the degree of polymerization of 20 and 50,were synthesized bypoly-glutamic acid benzyl ester (PBLG) with GA modified.Their structure was determined by nuclear magnetic resonance and infrared spectroscopy.The two materials were formed into NPs loaded the camptothecin via solvent evaporation method,the physical and chemical properties of the NPs were investigated by scanning electron microscopy,and the release in vitro was evaluated in vitro release study.Result shows the size of the NPs distributed between 50~300 nm and the NPs exhibited good stability against electrolyte solution.The entrapment efficiency and drug loading amount were 77.3%,82.4% and 1.4%,2.3%,respectively.The NPs had a good sustained release effect in PBS buffer solution,the drug cumulative release reached 50% in 8 days. The study laid the foundation for the preparation of NPs with active and passive double liver targeting property by the materials.
