In order to investigate the building floor’s twist and the frame column’s axial force due to shield tunnelling adjacent an existing multistory frame structure building,several typical sensitive factors were analyzed through the 3D FEM by considering the interaction of the shield tunnel, heterogeneous soil and existing building.The result showed that the stress concentration caused by shield tunnelling appears just at beam-column joints of the building corner, and the tunnelling-induced ground settlement will be restricted by the surrounding existing building.The clockwise rotation of the left-side building floor is caused by shield tunnelling.Before the tunnel excavation face promotes to the transverse centerline of the building, the twist of the building floor increases,while the axial force of the frame column decreases.However, the opposite results were calculated as the shield driving.The analytical results can be used to better assess building responses to tunnel excavation induced ground settlement.