The non-Gaussian features of fluctuating wind pressures on double-skin facade are systematically studied by using multi-channel measurement wind tunnel tests. Based on the wind pressure sample time series and histograms, the third and fourth order statistical moments of fluctuating wind pressures are employed to obtain a description of the non-Gaussian feature. According to the value of peak factor, the criterion of the regions with non-Gaussian features is obtained, and then the regions with non-Gaussian features on the internal facade and external facade are located, which is the corner of the internal facade. Finally, the necessity of increasing pressure’s peak factor of the regions with non-Gaussian features in structural design is put forward.