微小RNA在人牙周膜来源细胞成骨分化中的作用

Human periodontal ligament-derived cells are a group of heterogeneous cells, which can differentiate into osteoblasts, participate in remodeling and repair of alveolar bone remodeling, and periodontal regeneration. MicroRNAs (miRNAs) are thought to play a key role in the regulation of cell differentiation and be key factors in maintaining cell differentiation and regulating differentiation. MicroRNA plays a promotion or inhibition role on osteogenic differentiation by targeting mRNA. In this review, we summarized the different miRNAs in the osteogenic differentiation of periodontal-derived cells, focusing on the function and regulation of target genes and pathways under the mineralized or mechanical force induced conditions.