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论文摘要

造血干细胞移植后侵袭性真菌病的研究新进展

Advance in invasive fungal disease after hematopoietic stem cell transplantation

作者:

Author:

收稿日期:2019-11-18          年卷(期)页码:2020,43(03):203-209

期刊名称:国际输血及血液学杂志

Journal Name:International Journal of Blood Transfusion and Hematology

关键字:侵袭性真菌感染,造血干细胞移植,流行病学,诊断,药物疗法

Key words:Invasive fungal infections|Hematopoietic stem cell transplantation|Epidemiology|Diagnosis|Drug therapy

基金项目:

中文摘要

侵袭性真菌病(IFD)是患者接受造血干细胞移植(HSCT)后的常见并发症,其发病率及其导致的患者死亡率均较高。近年,由于新型诊断方法的出现、治疗策略的调整及新型抗真菌药物的应用,IFD的流行病学特征亦发生相应变化。根据IFD的诊断分级选择合理的治疗策略,有望降低HSCT后IFD的发病率及其导致的患者死亡率。笔者拟就HSCT后IFD的流行病学变化、危险因素、诊断方法及治疗策略的最新研究进展进行阐述。

英文摘要

Invasive fungal disease (IFD) is a common complication after hematopoietic stem cell transplantation (HSCT). The morbidity and mortality of patients with IFD after HSCT are high. In recent years, the epidemiological characteristics of IFD after HSCT has changed due to the emergence of new diagnostic methods, adjustment of treatment strategies and applications of new antifungal agents. Selecting a reasonable treatment strategy based on the diagnostic grade of IFD is expected to reduce the morbidity and mortality of patients with IFD after HSCT. This article summarizes the epidemiological changes, risk factors, diagnostic methods and treatment strategies of IFD among the patients who received HSCT.

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