Acute myeloid leukemia (AML) is a common hematopoietic malignant tumor. AML patients have poor chemotherapy effect and low long-term survival rate. To improve the chemotherapy effect and prognosis of AML patients is currently a clinical problem to be solved. The reason of poor chemotherapy effect and prognosis may be closely related to AML drug resistance. AML resistance is not only related to the biological characteristics of AML cells, but also due to bone marrow microenvironment. Bone marrow microenvironment plays an important role in AML resistance. To explore the mechanisms of bone marrow microenvironment mediating drug resistance, lays a foundation for targeted intervention to improve the therapeutic effect of AML chemotherapy.
