人类主要组织相容抗原Ⅰ类分子在口腔白斑中表达的临床意义
The expression of human major histocompatibility complex-Ⅰ in oral leukoplakia
作者：吴平凡 韩帮锋 夏辉 严超然 李龙江
Author：WU Ping-fan, HAN Bangfeng, XIA Hui, YAN Chao-ran, LI Long-jiang
收稿日期：2010-08-25 年卷（期）页码：2010,28(04):439-439-442
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：人类主要组织相容抗原Ⅰ类分子,口腔白斑,口腔鳞状细胞癌,免疫组织化学,异常增生,
Key words：human major histocompatibility complex - Ⅰ ,oral leukoplakia,oral squamous cell carcinoma,immunohistochemistry,dysplasia,
基金项目：
国家自然科学基金资助项目（30973345和30471901）
中文摘要
目的通过检测人类主要组织相容抗原Ⅰ类分子（MHC-Ⅰ）在伴有不同异常增生程度的口腔白斑中的表达，以探讨MHC-Ⅰ类抗原表达改变后其局部免疫状态的变化，以及与口腔白斑发生的关系。方法应用MHC-Ⅰ特异性单抗通过免疫组织化学方法从蛋白表达水平检测28例正常口腔黏膜、55例口腔白斑、31例口腔鳞癌内MHC-Ⅰ类抗原的表达。结果伴有重度异常增生的口腔白斑与口腔鳞癌内MHC-Ⅰ类抗原的表达显著低于正常口腔黏膜组（P
英文摘要
Objective The purpose of this study was to examine the expression of human major histocompatibilitycomplex-Ⅰ at different degrees of dysplasia leukoplakia, and to investigate local immune status and discuss their associations with oral leukoplakia. Methods The monoclonal antibody of MHC classⅠantigen was employed in this study. There were 55 oral leukoplakias, 31 primary oral squamous cell carcinomas and 28 histologically normal oral epithelia were detected for the presence of the MHC class Ⅰ molecule by using immunohistochemistry method. Results The MHC class Ⅰ antigen expression of the severe dysplasia and oral squamous cell carcinoma was significantly lower than that of the normal epithelia（P
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