人端粒酶逆转录酶与c-myc和刺激蛋白1在成釉细胞瘤中的表达
Expression of Telomerase Activity and c-myc and Stimulatory Protein 1 in Human Ameloblastoma
作者：钟鸣,李自娟,王洁,张波,候琳,宫雁冰
Author：ZHONG Ming1,LI Zi-juan1,WANG Jie1,ZHANG Bo2,HOULin2,GONG Yan-bing1
收稿日期：2004-12-25 年卷（期）页码：2004,22(06):499-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：成釉细胞瘤,牙源性角化囊肿,端粒酶逆转录酶,细胞癌基因,刺激蛋白1,
Key words：ameloblastoma,odontogenic keratocyst,telomerase reverse transcriptase,cellular oncogene,stimulatory protein 1,
基金项目：辽宁省自然科学基金资助项目(20032057)
中文摘要
目的 研究原癌基因转录因子c-myc和刺激蛋白1(SP1)在人成釉细胞瘤(AB)中的表达及与端粒酶逆转
录酶(hTERT)的关系。方法 选取54例AB(原发31例,复发19例,恶变4例)存档蜡块,采用原位杂交检测AB中
c-myc mRNA、hTERTmRNA的表达,采用免疫组化SP法,检测AB中SP1蛋白的表达。结果 c-myc mRNA在AB中
阳性率为81·5%(44/54),hTERTmRNA为94·4%(51/54),SP1为83·3%(45/54);伴随AB的复发与恶变,3者表达强
度上升;相关性分析得出hTERT与c-myc之间存在相关性(rs=0·853,P
英文摘要
Objective To study the oncogene transcriptor c-myc, stimulatory protein 1 (SP1) expression in ameloblastoma (AB) and their relation with telomerase reverse transcripase (hTERT), and to investigate the clinical biological characteristics of AB.Methods The expressionwas observed in AB by in situ hybridization and SPmethod.Results The positive rates of c-myc mRNA, hTERTmRNA and SP1 protein were 81·5%(44/54)、94·4%(51/54) and 83·3%(45/54), respectively. Their positive rates increased as AB recurred and transformed malignantly. A strong correlation was found between hTERT and c-myc, hTERT and SP1 (rs=0·853,P
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