口腔癌前沿细胞基质金属蛋白酶-2表达与颈淋巴结转移的关系
The Correlation between Neck Lymphy Node Metastasis and Matrixmetalloproteinase-2 Expression at the Invasive Tumor Front of Oral Squamous Cell Carcinomas
作者：刘来奎,李怡宁,江宏兵,何志秀,易新竹
Author：LIULai-kui,LI Yi-ning,JIANGHong-bing,HE Zhi-xiu,YIXin-zhu
收稿日期：2004-04-25 年卷（期）页码：2004,22(02):106-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：口腔癌,基质金属蛋白酶-2,淋巴结转移,肿瘤侵袭,
Key words：oral cancer,matrix metalloproteinase-2,lymph node metastasis,tumor invasion,
基金项目：
中文摘要
目的 探讨基质金属蛋白酶-2(MMP-2)在口腔粘膜鳞状细胞癌中的表达特点及其与颈淋巴结转移的关系。方法 应用免疫组织化学LsAB法观察MMP-2在口腔癌生长前沿区与中央区细胞中的表达分布特点,并分别与颈淋巴结转移发生进行统计学分析。结果 71例口腔癌原发灶均有MMP-2表达,在口腔癌生长前沿区细胞的表达明显强于中央区(P0·05)。结论 口腔癌生长前沿区细胞MMP-2 表达明显强于中央区,与颈淋巴结转移有关,可作为口腔癌颈淋巴结转移的预测指标。
英文摘要
Objective To explore the correlation between neck lymph node metastasis and matrix metalloproteinase-2 expres- sion at the invasive tumor front of oral squamous cell carcinomas(OSCC).Methods Immunohistochemistry LsAB technique was used to observe the expression of MMP-2 at the invasive tumor front and center of OSCC, and the correlation between the expres- sion ofMMP-2 in OSCC and neck lymph node metastasiswere respectively analyzed by statistics.Results The results demonstrat- ed thatMMP-2 existed in all 71 cases, which the expression ofMMP-2 at the OSCC frontwas more significant than that ofMMP-2 at the OSCC center (P
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