肿瘤耐药蛋白在舌鳞癌中的表达及意义
Expression and Implication of Pgp, MRP, LRP, GST-π, TopoⅡαin Tongue Squamous Cell Carcinoma
作者：冷卫东,王大章,冯戈,何嘉
Author：LENG Wei- dong,WANG Da-zhang,FENG Ge,HEJia
收稿日期：2004-02-25 年卷（期）页码：2004,22(01):23-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：舌鳞癌,多药耐药,P-糖蛋白,多药耐药相关蛋白,谷胱苷肽-S转移酶,
Key words：tongue sequamous cell carcinoma,multidrug resistance,P-glycoprotein,multidrug resistance-associated protein,glutathione-S-tranferase,
基金项目：
国家自然科学基金资助项目(39970798);四川大学优秀博士论文研究基金资助项目(0040305505010)
中文摘要
目的 检测P-糖蛋白(Pgp),多药耐药相关蛋白(MRP),肺耐药相关蛋白(LRP),谷胱苷肽-S转移酶(GST-π) 及DNA拓扑异构酶Ⅱα(TopoⅡα)在舌鳞癌组织中的表达水平及与化疗疗效的关系。方法 采用卡铂、平阳霉素和氨甲喋呤化疗方案对40例舌鳞癌患者进行化疗,分别于化疗前和化疗后用免疫组织化学LsAB法检测Pgp,MRP, LRP,GST-π,TopoⅡα在80例舌鳞癌组织中的表达,其中40例为化疗前,40例为化疗后。结果 在检测的舌癌组织中,化疗前Pgp,MRP,LRP,GST-π,TopoⅡα的阳性表达率分别为47·5%,50%,35%,45%,82·5%,它们的表达与临床病理无关(P>0·05);Pgp,MRP化疗前后水平上升(P
英文摘要
Objective To explore the correlation of chemotherapy efficacy in tongue squamous cell carcinoma(SCC) with ex- pression level of P-glycoprotein(Pgp), multidrug resistance-associated protein (MRP), lung resistance-related protein (LRP), glutathiones-tranferase (GST-π), DNAtopo-isomeraseⅡα(TopoⅡα).Methods The expression patterns of Pgp, MRP, LRP, GST-πand TopoⅡαin 40 patients (pre and post-chemotherapy, respectively) with tongue SCC were examined by immunohisto- chemically labelled streptavidin bioein method (LsAB).Results The expression ratios of Pgp, MRP, LRP, GST-πand TopoⅡ αin pre-chemotherapy cases were 47·5%, 50%, 35%, 45%, 82·5%, respectively. No relations between expression of Pgp, MRP, LRP, GST-π, TopoⅡαand clinic indexes were established (P>0·05). Expression ratios of Pgp, MRP in post-chemo- therapy cases were higher than that in pre-chemotherapy cases (P
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